Streptococcus agalactiae do not penetrate human chorioamniotic membranes in vitro but alter their biomechanical properties

Introduction Vaginal colonization with Streptococcus agalactiae (group B streptococci) is hypothesized to constitute a risk factor for preterm prelabor rupture of membranes. In vitro studies have shown that S. strains isolated from infants neonatal sepsis adhere chorion cells the human chorioamniotic membrane. However, it still unknown whether penetrate membranes and affects biomechanical properties thus contributes increased rupture. The aim this in study was explore if different affect Material methods Three were obtained, one an early-onset infection, case healthy pregnant carrier. Chorioamniotic elective cesarean deliveries either incubated or mounted two-chamber incubation cell generating “maternal” “fetal” chamber maternal chamber. Subsequently examined evaluate attachment, penetration effect on properties. Results At 5 h after incubation, adhered number at 20 h. did not even incubation. ultimate tensile stress needed work as well elastic modulus. Conclusions Human physical barrier against infections. Moreover, infection leads strength